A dynamic water quality model, HYPE, was applied to a large, data-sparse region to study whether reliable information on water quantity and water quality could be obtained for both gauged and ungauged waterbodies. The model (called S-HYPE) was set up for all of Sweden (similar to 450 000 km(2)), divided into sub-basins with an average area of 28 km(2). Readily available national databases were used for physiographic data, emissions and agricultural practices, fixed values for representative years were used. Daily precipitation and temperature were used as the dynamic forcing of the model. Model evaluation was based on data from several hundred monitoring sites, of which approximately 90% had not been used in calibration on a daily scale. Results were evaluated using the Nash-Sutcliffe efficiency (NSE), correlation and relative errors: 92% of the spatial variation was explained for specific water discharge, and 88% and 59% for total nitrogen and total phosphorus concentrations, respectively. Day-to-day variations were modelled with satisfactory results for water discharge and the seasonal variation of nitrogen concentrations was also generally well captured. In 20 large, unregulated rivers the median NSE for water discharge was 0.84, and the corresponding number for 76 partly-regulated river basins was 0.52. In small basins, the NSE was typically above 0.6. These major achievements relative to previous similar experiments were ascribed to the step-wise calibration process using representative gauged basins and the use of amodelling concept, whereby coefficients are linked to physiographic variables rather than to specific sites.